University of South Carolina Libraries
PELLAGRA AND BLIND STAG GERS. Is is Argued by Some That There is a Relationship Between the Two Diseases, the One of Man kind, the Other of Horses. .\:~~ ~ ~~ hnll:a 1) nernc.bhIr. nP.WCp1. pe'rhapos. w:1.4 -,,at bw Dr. 3L :B P:mers of(' lemn cole the State veterinarian, who suspet-s a relatlonshio between pellagra huma11n p:tients and blind siav:''ers in 1"C histor aml' descriptin uof t his fata! dise:se of hIorses which is of common nec-arrece in this State durinz wet "Dr. Large of New York first re ported this dease in America in 1850. In 1852 and 1865 it appeared in Den mark and Germany and a very ser ious outbreak was reported in Egypt in 1876, where about 6.000 horses, mules, and asses perished in the vi cinity of Cairo alone. "Since its first appearance in this country numerous outbreaks ave been reported at frequent intervals. An outbreak occurred in Virginia and North Carolina in 1886 and assumed such proportion that the citizens of these States appealed to the United States department of agriculture for aid. In response to this appeal, Dr. W. H. Harbaugh of the bureau of ani mal industry was detailed to make an investigation and his report was published in the third annual report of that bureau. Another serious out break occurred in Kansas in 1901 and was investigated by Dr. Mrayo of the Kansas agricultural experiment sta tion. The result of his investigation was published in bulletin No. 24 of that station. "Frequent outbreaks of this dis ease have since been reported in New Jersey, Maryland, Virginia, North Carolina, South Carolina, Georgia, Louisiana, and other Southern States. In fact, this disease now occurs al most every year in different portions of the United States and its appear ance is now expected after rainy sea sons similar to those .of 1901 and 1906, when molds and fungi thrive on fodder and grain. ''The records of this officee show that in 1901 this disease appeared in at least nine counties of this State and caused a loss which was estimated as exceeding $10,000. Following the wet snumer of 1906, the disease again appeared, and, judging from the cases already reported, we may expect an other serious outbreak this winter. ''Severe losses occurred in other Southern States during these same years and D)r. R. W. Mickman of the bureau of animal industry spent con siderable time investigating an out break in North Carolina. His report is now available as circular 122 of that bureau. Occurrence. ''This disease does not seem to be confined to any particular locality, as it has appeared in the upper portions of the State, as well as in the lowei country. We must admit, however, that outbreaks are more frequent in the low, flat country than in the hilly portions of the State. Horses are more frequently attacked than mules, in fact, I have never had opportunity to see a mule so affected, although the loss of a few mules has been reported to this offiee. ''Cases occasionally appear spor adically, although more frequently the disease extends over a large area, hence the name, 'epizootic cerebro spinal meningitis.' It is rare, how ever, for this disease to attack all the horses on one plantation. Cause. ''While many theories have been advanced as to the causative agent, we are compelled to admit that the specifie cause is unknown. The cause has been attributed to almost every thing from unsanitarv condition of the stables to sudden changes in the Sweather, but while we must admit that these may be predisposing caus es, we know that they are not of prn mary importance as causative factors. ''No pathogenic microbe or virus has ever been isolated as the causa tive agent. Furthermore, we have Ioften noticed that the disease is not Scommunicable from animal to animal, as it frequently happens that one horse in a team may be affected. while the mate, which ha.s been kept undet identically the same conditions (eat ing from the same manger, occupying the same stall. etc.), rem-:ins perfect ly healthy. This and other observa tions lead us to believe that the symp Stoms are produced by the introductiot f soemnarotic+o ison rather than by the _,rowtli of micio-rganum:l 8:n within the system. 1! "If these symptoms are produced le by micro-organiins our Iaboratory I Imethods must be at fault or t'ie 01 ganisI must be ultra-microscopie. fi Furthermore, the inoeulation intc f( suseeptible animals of defibr -ce '1 I :1nnot bel) m-epted. hmev~er, as a l;re111111Iber ofr a11111mals Wl-6il Z1, :!"0 :no T kep 1u(ler idenl"ically thea 'I <aminged corni. TIiis last t eI firther ztren*thened by the (b.erva- fl tion that when owners of affected e animals change the food and water e\ completely no 'further eases develop. in while in instauces 'where owners re- i fuse to do this new cases appear- T "'D-. M1ayo's investigations woulId o(-f lead us '- believe that the symptom6 et are produced by a fungus (sapergil- ru lus glaucus), the spores of which en- rci ter the c'reulation Pnd cause inflam- ti: mator- conditions and abscess of the le brain. He claims to have recevered Pt this fungus from the lesions. e 'While damagred food is probably i the fost rational cause of the diPe.a-s (, we must not overlook the fa%-t thiat i iseveral investic tors have carried oi., feeding experiments with neativt re-a itl. Dr. Law explain s h s nd re fs-e that .l anials receiving dama - w ,d food are not affected by stgtosta I ' that the crypptogam proh-ably var.v i under different conditions of life and p, elaborate various proucts at differ ent stages of their growth, thus ae- se counting for the presence of the dis- tr ease at one time and its absence at ar another under what may seem indenti- a< al conditions . se SympHtcams toav orec Th fgsmptomsth lsionly exibte "Wie dlmessand xrm usculoari t theakns ration bycangi of the te we mstnot oeralyssof the fatthat, eI m eainesallorsngv difcaior is sei nd exlvaerimens frothe moth t Parits is.a exlasinll thisen and et f'th al animals end f laormay- a stad foth ae legs affeed hr swth body staesing agairs rth thde aof the sotinge Twtcinro the enecltes dis tr aoterobserd watd may seeme indetn- ae cal,conditid ontrctono crti o grohipsymuscles usal xhice.Am-d wakns (shwnbecme haningios thnd heand with teeadepressed) Therns I isthen al aralyesisoftetrat cirT sele and tempraureings frmoth te thnormal sta05r and Fallhorugh it som istane ith lemis ncdormawior a boyvenstnrmagans hesitiof the di ofete obsrvd, and, nlse rianb- c i softeand bee,i someicass and harand wi othes herse vgisl e thoe aore wally pertey inch cir- T ge.sTe meaur agsrmc norma to 10 hor 106 F.ial althoghin t sfter nacsr tm remainna on ] ev cmtsbcmnditsionautioni d ath -I celerd as the animlse vayrbe,ove-, ibgot arnsedo wea inc some. cas they duseveonoa are comonly vererchco- - ede'ducses usull mortalithin sixuth 4Carolns t anals fallicnt. E aferash orttie Apperaningin. a'Cmtongstioo til death. vesel mil themenes anml mdla reae bt ecnt n areslo fmc ai as nerteF deoprnt softeednrutie monl otem F Sound. Carona isatlaste 95 perticul ofr th sofennes andrphoull apear ger than a silver dollar was found in the left cerebral hemisphere. In con nection with this I might add that0 the horse was apparently in normal1 condition when placed in the stable IS at night. bu! was delirious when found in the morning. This horse died I within six hours and (as this lesion' * The First Cough Evezi though not severe, has a te * tive membranes of the throat a OCoughs then come easy all winti *alightest cold. Cure the first coi * set up an inflmations in the delici * lungs. The best remedy is! SSYRUP. It at once gets right ~ moves the cause. It is free fron * a childas forn aduIt. 25cenlts MAYES' DRL aist have been wel! develtyed herore e symptoms appeared) the hope asncss of medicinal treatment is at ice apparent. -Five brains hIave been for-sardetd( JInI thil ,%Oflie to Wahington. C., r examination and the following is extract f,on a ' reeved from :n1dat ive and sh!Ow thle ahtrisi -ery resp)ect simiilar to toefounld epizootie- leueo encephalitiz. isul termedir eerebro-spinalmniiis hie blood vesselse in the suib.iance thie brain pre.sent .m infl-:nmntorl midition of the waIls, somie beIZ iptur-ed, others distended. The smn Iunding tissue shows s perivaseii ; and contains many :nfiltrated aeoeytes. The softened centers ap 111 a. Cr . ' bava haline or gelatinous degaenl 'Zited areas of a homogreneouas na re. which is frequently seen to be intracted, leaving vaenoles contain i a faint fibrinous material. Thi 1ro2lia fibrila show a gradnal dis laio,whih .. also apa-ent in ' 11111olia Hel. fie protnplatsm of hicr%ehI fai!s i to take any itin ei-ote le()eepl.i ua ain. blodhesere fini thr e - btilce tothe ebrinrsen on ithe omtoen 11rts. '''The location of the above de ribed softene dareas probably con ols the various symptoms produced id would account for the different tions of the animals you have ob nrvted. Treatment. ''Mediinal fireatusmei ustis etoryatand praicsalsy aseless, ias e centra nevous stem hrtpasm osal angefis teo thec syts develop.v hein th~e ae im alsis noticd befor tae aly to swlow is lost, aepur 'einj cation of heo aoee ribe oftriu dalries probabl on-e ''s the vaiseaeus spom fatal,eer oid woude cutohe iffesread. beon anial the ils yompeteb raneo. od'n atrad oe "andinal stame is thrusatis sinfct and prcallydt ueless, va ''Whergthee msur e ardot ange additoal cases smptoms develop." -he The niasisnorai fr en abltaswalow Hapes lot,agaziur Ie is laghinistemrad :hnh iciectipos own erit o awed.~ Idbhave evr feltraveousd. c nof barinds choee trs gieto me, Andis the samse pupne myodid "Asethe iease biss orftl w e er lois adw ton chec so ead age ofo adnat perperand floved Uandernet stbem i the thorod.l sallerte tand teallet reaint,a Lntrfor twoan the mont hole ne"nWhe divied mearesaeatt Ad the ie raol. lient Glaes, entHrpers agazne Ancent, sulndeae fren, Uiverse larein on mye.ad ofethe po oni Sea nd, + orn the wirritte tys senith me r,nver tme r shae my joy [g eore hi ors or ea.c t It capilar and tuesof te .tethr fear o r bl or wo fe andphieah pereal flow. Unenet te Ia,Gd Ancietr E. e Old People s asimiatin, nribesthte blood, 1l Vcn ivery o:r in th( . I Ei :ua onrVn We are positive it will benefit everj old1 Person wh-!o wvill -ive it a trial If it don't :ewlreudtheir m1oney William E. Pelham & Son Newberry, S. C. EYE SYMPTOMS Do not always make their presence known by failing of sight. Red Lids, Headaches, Nervousness, Stomach Disorders, in most cas-es can be traced to im perfections of the eyes. We do cu,re troubles of the above kind with glasses. DR. G. W. GO0MOR, Newberry, S. C. Office Over Copeland Bros. Store. TA T .0FSUHCAOIA CONT O EWERY INCOURT~ COMMO PLAS ~ini t!l ~vAgrains ninth William M. Ridehbr J. H.oRi lehwb erry .ilhbr Walte Douno adwThe Seteir opresence Henadaches Byorervoflsthesuts eei,I,i seln beortcs~ e traoue tooirn Terfectio, of th, onModa,ehe7t d.ay (10 Dceb)er, 908 the sameoe insda wit hintheasgaesou estae inNewberry, S.nt C fwhc Offibe Oands opelan Bo. Stack,e.' MrtgaW L. eitzs, Goryg.eiBun drick Ameli ote. aicke ands wgill E Tat o Plitif,thhoera,cn taiingonehunreaindfvean NW.3idland of RiW.e . H.itzey Ter, N. D. Roiningber Waneu T-5 Riacbr, morirlstiand ubr,ndet ber land ThDae Ster, Gorgepany,D fdrkants at.o adN.3 TractNo.,Pcotiin n u Byedrded ofine cour heinfty-fiveo hundbefrethe (10o55100 hoes doora Newberrs, and.o bounddy thts o adN.2ayad of Deebr198thae ube1 isaleda,wti.helglhu Trsof sale: Tihes purchaer te pea: ontanig-thirdcahndehiod and<e ty (320)gacroe o ress, onh eedity latind of R.he Stck,s Wonej ptbinW two eiequa Georal insta dmeknd withiners Said thenday wil: sld in thre saate egtacts aseno paraleNo 1,ual the he fret cot aingon wihunavedo andive pan oetfourthe (credit4 aron mor wo pers3 and recodin of Wsam eie. Tract No. . tiin. n Rikr bylans of ave S MrsteoreBu drMkantercsie No. 10ad. 10. dHdandbinced ad imy-fie-oruin hundrehs M(15P0-00 C E s, mo fewN.2 n leeks. Yof aner tou homee Epin D. dA. Diwet, .n hap P It will be ehbitd on dpcay fo on-tir cah and cuv huis bonRa Adds it irest R fro the daOoE A Chec C 2 the loss N o carelessi H IS metho( deian(ls that Tmj. I OP V'~ in t'-e ink wher we.1 emlo ehe~ C e meanstv liv.*- to loss when funds are in our by care. We give you safety. gav t is is n. -alhso"u --h IThe Com NEWBERRY JNO. M. KINARD, 0. B. MA7 President. Vice-Presi We Lend TO BuyH We provide easy terms a We enable borrowers to in Monthly Installments, oi allowed to meet obligation It is cheaper than paying to save money to buy a hoi Contract. If you want to save mone take a Security Contract. SCall on A. J. Gibson, Ass Treasurer, at off ice; cornei stre.ets, next door to Gopel SECURITY LOAN AND11 ityuae feelig o a MEDY" strenghens te Stoa ples, eth Bt neer gripes, I invariably making the user feel str< Better Than Pills Fc Apptet Salow Complexion, ie Coi from the digestive organs. Geta . TO' Box.dI William E. Pelham & Sor YOUR BA STHE NEWBERRY SI Capital $50,000 -- No Matter How Small, N The Newberry SE Nill give it Careful attenti 1ppies to the men and the JAS. M"ciNTOSH. T'resunt k Account prevents of money by theft, iess or accident. IT11 :or money in the IVU, bn)U mav issue a :k agains iK:. Your chccks good only whcii properly ed, anc b~I)e ca-hed only the party to whom you e it, who nust endorse it. S ie con ence 1;trge ~iaI Bank, ,s. C. 7ER, J. Y. McFALL, dent. Cashier. Money >mesl. f payment. accumulate a fund m which interest is - at maturity rent. If you want ne take a Securitar py for any purpose It pays. ant Secretary and rBoyce and Adamus and Brothers. I VESTMENT CL. g:gt:T m, 0. tae an NRA tab. - i the morrning. gh 'NATURE S rk thoroughly and eakns or sickens ~ner and better. r Liver Is. k Headache, Loss of pinSki n s ea ad all troubles arising ~Taibet , Newberry. S. C. N4KING! LINGS BANK, -Surplus $30,000 'o Matter How Large, tvngs Bank on. This message women alike. .E. NOR wOOD, Ce.:.r.