University of South Carolina Libraries
PELLAGRA AND BLIND STAGGERS. I Is is Argued by Some That There is a Relationship Between tho Two Diseases, tho One of Man( kind, the Othor of ^ Horses. AI I lie ;>e!la-ra conference held ,T_ I I'ciill.v iii ('oliimhi.i. III., must iulorest>ng |?a|H'r, perhaps. was that by |)i. j M. Ifav ['.avers of Clenison college, )llu State veterinarian, who suspects : relutionship between pellagra i-i human pal icn(s and hliii.l slaters in animals. His paper caused mtx-l. comment. Til.. subject was 1* 'I'll,. ' S,,P"'' ! IMali.!rip ,,r | 'I <'11 i! I '! I Is . J i I I - .1 * * :vipfr its,.11* is as l*??!?..w- ; " ' I '' t'<i(|c|i| aii.l (!cii11 <*iIi<*11: "I will 4'in]i>av<ir ?|v,. bri.-f history ami description of this fata' disease of horses which is o|' conmi..i, o-ertir,i? ,|,i; S|.,fM during wer j seasons. Dr. Large of Xew York firs I reported I his .lease in Anieriea in 18.">0. I In 18,2 and 1Xfi:> i| appeared in Denmark and (ierinany and a verv seiL ions out break was reported in Egypt | in 187(1, where ahonl 0,000 horses, mules, and asses perished in the vicinity of Cairo alone. 1 "Since its first appearance in this country numerous outbreaks have I hoon reported at frequent, intervals. \ ^rn 0,,,1"'?nk occurred in Virginia and North Carolina in 1880 and assumed such proportion that the citizens of ; ',10S0 States appealed to (lie United \ .Stales department of agriculture for A a,jb Tn response to this appeal. Di. i W. II. TTarbautrh of (he bureau of aninial industry was detailed to make an | ,nveslitralio? and his ,-eporl was f published in the third annual report | of thai bureau. Another serious outf "reak occurred iu Kansas in IfKll and I investijrntod b.v Dr. -way., of the j Kansas agricultural experiment sta; tion. I lie result of his investigation was published in bulletin No. 21 of j that station. "Frequent outbreaks of this disI> easc I,avc since boon reported in Now fj Jersey, Maryland, Virginia, North > Carolina, South Carolina, Georgia, : Louisiana, and other Southern States! ij ^act, this disease now occurs alii most every year in different portions i' of t,lc United States and its appearI an(>e is now expected after rainy seajft sons similar to those of 1001 and il' w'ien m?W? and fungi thrive on f|.' fodder and grain. Ik '.'10 10('?l^s "'is oflice show || that in 1001 this disease appeared in $ at least nine counties of tins Slate itv and caused a loss which was estimated as exceeding $10,000. Following the j':;,. wct summer of 1900, the disease again appeared, and, judging from the eases already reported, we may expect au?^lcr serious outbreak tiiis winter. 1"Severe losses occurred in olhot fii.;} Southern States during these same .years and Dr. Ii. W. Mickman of the bureau of animal industry spent eon| siderable time investigating an out| break in North Carolina. Ilis report I is now available as circular 122 of that bureau. Occurrence. " I'll is disease does not seem to be f, t'onfined to any particular locality, as it has appeared in the upper portions of the Stale, as well as in the lowei ,v countr\. We must admit, however, I bat outbreaks are more frequent in I lie low, flat country than in the hiM\ 1$ port ions of (he State. Horses are ) more frequently attacked (ban mules, ; in fact, 1 have never had opportunity to see a mule so affected, although the r|.| loss of a few mules has been reported fegf fo this oflice. < i j (v ''Cases occasionally appear sporadically, although more frequently disease extends over a large area, M bonce the name, 'npixootia cerebro1]. spinal meningitis.' It |s ,-aro, how^ ever, for Ibis disease to attack all the ;{? horses on one plantation. j$ Clause. "While many theories have been advanced as to the causative agent, $ we are compelled to admit thaT the j specific cause is unknown. The cause has been attributed to almost everyk rliinar from unsanitary condition of Iho stables to sudden changes in the weather, but while we must admit. ^ I hat these may be predisposing eausj es, we know that I hoy are not of primary i in port a nee as causative factors, j "No pathogenic microbe or virus has ever been isolated as tho causative agent. Furthermore, wo have often noticed that the disease is not communicable from animal to animal, as it frequently happens that one j horse in a team may bo affected, while the mate, which has been kept undei identically the same conditions (eat1 ing fioni the same manger, occupying I the same stall, etc.), remv.ins perfectI ly healthy. This and other observations lead us to believe fliat tho sympI toms are produced by tho introduction * of some narcotic poison rather than " \ by tin* growth of micro-organisms In within the system. 1 "If those symptoms are produced ! 1 by micro-organisms ?ur laboratory | c methods must be at fault or t|ie organism must be ultra-microscopic. j I Furthermore, the inoculation into ' I susceptible animals of dofibrinatod t :i "lid citrated blood, as well as biwin ! ciujilsimi from alVected animals, fail.- I :i to produce these symptoms. "Poisonous nlauts have also I ' r suggested as I he possible cause. Thi> I r cannot be accepted, however, as a Ji large number of animals which es- I ;i capo are kept under identically tlu-isame conditions as.the animal, which i I arc a fleeted. , : "As j .; ;??-! it- ?11 \ ? \ e:-v -ml hp-ak ! **Tlu!;:i I- re. i'l-.. .I , , . I ...... i . ! ne map'in'y o' mi- !i vcn| ij>-alor< believe ihe c.i:i-ai i v< 1'i J a >i |o be ne \ !d- ?>r funiri wliieh ; .-i vr-nv nil the d t iing. ,[ f.?,.,|. I',-.. -, j ? invest igal ions and from reports re- j( ( cived, il would be dillieult |o eon- ; j 'iee| ('tis di.-easo \- i t! I : >i \ par? icnla: Iood.'all hoii'jli in the majority "I li eases the alVecled animals received damaged corn This last theory i-i", jluclher -1 rongl lieued by the observa- I i' lion thai when owners of affected j animals change Ihe food and water completely no further cases develop, j while in instances whore owners re- i fuse 111 do this new cases appear. 'I "Dr. Mayo's investigations would n lead us to believe; that Ihe symptom.- c are produced by a fungus (sapergil- r lus glaucus). Ihe spores of which on-j r lor the circulation and cause inflaiu- j( mator.v conditions and abscess of tliell, brain, lie claims to have recovered \ e Ihis fungus from the lesions. i "While damaged food is prohahl\ |? Ihe fosI rational cause of the disease. . c we must not overlook the fae| lliai'i [several investigalors have carried on ! n i ling experiments wilh uegat've re- ji .suits. Dr. I,aw explains lliis and the I j I t lh:il all animals rcceiviiej daniag- v | ed food are not alVecled h\ statin-: s j'lhal Ihe cryptogam* probablv var\ j i! under different conditions of life ami i | elaborate various products at different stages of I heir growth, thus ac- s counting for Ihe presence of the dis- | ease at one time and its absence at ;1 another under what may seem indenti- a oal conditions. S( Symptoms a.nd Course. "The symptoms usually exhibited are dullness and extreme muscular ' weakness (shown by hanging of the ' head and general depression). There is often a paralysis of the throat, <' making swallowing difficult or impos- ^ sible and saliva drips from the mouth. ' Paralysis is occasionally present and " the animals stagger and fall or may a stand wilh the logs braced or with 11 body resting against the side of the stable. Twitching of the muscles is I' often observed, and, in some install- e cos, a rigid contraction of certain ? groups of muscles is noticed. Am- b mals often become delirious and stand wilh the head pressed against <! the wall or walk persistently in a eir- ' do. The temperature ranges from (* normal to 105 or 100 F., although in I some instances it. remains normal oi a even subnormal. Respiration is ac- d colerated and the pulse variable, be- c ing soft and weak in some cases and hard and wiry in others. The visible c mucosae are usually very much con- ? gesled. " Revere.,, cases usually die within six to 48 hours, the animals falling Tafter a short time and remaining in ^ a comatose condition until death. Tn mild cases tin4 animals may rocovoi, V bill are seldom of much va'fio, as I hoy develop into what are commonly term- , od 'dummies.' The mortality in RonIh Carolina is a! least 0o per cent. ^ Post Mortem Appearance. "( (ingestion of Ihe blood vessels of Ihe meninges and medulla appeal I to be constant and areas of necrotic I* or softened nervous tissue are often I. found. Tn one instance, in particular, a softened amorphous area lar- 4 ger than a silver dollar was found in K the left cerebral hemisphere. Tn connection wilh this T might add that ( Ihe horse was apparently in normal condition when placed in the stable S at night, but was delirious when found in Ihe morning. This horse died I within six hours and (as this lesion' J The First Cough 0 Krett tkough not oevore, has a t< of the throat s ft Coughs tken come easy all winti slightest cold. Cure the first co v ?et tip an Inflamatlon In the delic ^ l?ags. The best remedy is i ^ SYRUP, It at once gets right ^ mov?"S the Cf.use. It Is free frotr a child as tor an adult. 25 cents 2 MAYES' DRl * ***-< A imsl have been well developed bo fore he symptoms appeared) the hopeessness of medieinal treatment is at nice apparent. "Five brains have been forwarded V.?:n this otliee to Washington, J). C., or examination and the following is in extract from a ltd tor received from he a<| ing chief ??(' the bureau of am- J n il ii!< 1 itv! ; v : i i 'I |"'il It! . I ; ' . i e -e li-stles' 1 'ahlnl - were iiiiumi);i! c?! in; r.i< < I;- I al!v with :i .?!?'.?t ?: a {; . - In-; I i i . i lev lave !itii< ,?r rc:n 11i'i ::: ! I'I' iieii Iv !ie::];!i> . oi.iiti't, I'p-n i 11i11v!' thron'.'h ii;e !? *,,! |~ an! rrev ;!; ; r I - ? l>, , . ... ; , ; "T r'Vv ' 7 U lie prcd'lcciimi for iin* n >; >v .u- ;.:- ;:i '' " '!! lv. 'r vj,!.. w.i., :n ... V !, v. . , . ;; :i!i!iv :it-:i: rrl. i-.t wji< ib- r*vd : v.-.iMid ! he ,< >ol :n -,1 J.,!"! . , >? n'.i i ii. y '<>!; iiilciMs' M.ii . x.:: i! 11.: ; i. : j lie.-e ;in| ! _;? 111' I i.>11 were' O'llld In lie destructive rather 'I III xtidalive and >liow the aijcr.i**;,ius 11 ; E| very respect similar to tli<found IB n epizootic leuco encephal'.! is. i>^n:'l-|K \ termed eerebro-spinal 111s1:iii11_i' i>. I B 'he blood vosselse in the substance B f the brain present .hi infhrnnmlot^ j ffl ondition of the walls, some bci'iu j B nptnrcd, others distended. The sin- j 3 ounding tissue shows a perivasenti-' 3 is and contains many infiltrated j iMicocytes. The softened centers ap- g ioar as hyaline or gelatinous degen- g rated areas of a homogeneous na- J fflore, which is frequently seen in '"-jK ontraded. leaving vacuole-- contain- 0 iig a faint fibrinous material. Th. jffi enroM'lia f'ibrila show a gradual ("S"|B rat ion, whicli - ahn apparent in ffi lie neuroglia cell-, tin* protopl <>m J&j k*!ii -!i fails t,. I ;,l<e any d:-'b>.-!'.v, ' $ tain. 'I'lieve :ire t'ina::v l?r '; . '-.wo %{ ' to t lie debri - : lie I ' ;11.?j .h larts. flic location of the ahove di-iffl cribod softeno dareas probably con- ! Kg rols (ho various symptoms produced ?5 nd would account for the different wj ctions of the animals you have ob- M I'rved.' n Treatment. j K "Medicinal treatment is ;msatis-.M aelorv and practically useless, a->j^' lie central nervous system has im.al- ,7! v undergone such degoner:?i ive hanges before the symptoms develop. Vhen the animals is noticed biv/ore ho ability to swallow is lost, a pnrrativo is administered. When the nimal is unable to swallow, hypoderiic injections of osorin or arecolrvivdrobromate or intravenous in.jec- j ion of barium chloride is given to ac omplish the same purpose. Todide ^ f potassium is also given when nossilo. "As the disease is so fatal. ever\ tTorl is made to check its spread.) 'he animals are given complete y hange of food and water and moved r> another stable if possible. Th:- ' bandonod stable is then thoroughly oj isinfeotod and allowed to remain va* ant for two or three months. "Where these measures are adopt-] d, additional cases seldom develop." , -The State. C( The Immortal. ! ^ -lien (ilasgow, in Harpers Magazine, once mv soul ;lud T are friends, , 1 go laughing on my road; \ helhor u)> or down it wends, T have never felt my load. < >* 'or the winds l<eep tryst with me. | le And the stars share in my joy: j \ Tondow, hill or sl<v or sea. T create and 1 destroy. jdi I 4l(?l?e or fear or bliss or woe Mils a shadow on the sod; life and Death perpetual flow. Underneath them T am find. (I mailer than the smallest part, hi Larger than the moving Whole; ?i bio in the divided heart at And the Universal soul. 1 ^ 'ilent, deathless, centred fast, i Ancient, uncreated, free, came no( to birth at last, ! I niverses are of me. ^m i ??a?Hwm?c | ,r fife "" of the Season, j; indency to Irritate the senvl- im ind delicate bronchial tubes. or er, every time you mkr ? pe ugh before it has a otiance to ate capillary air t?lx?s of the fir, QUICK RKIJKK COU(;i{ it th- seat of ti uble ae > rr M i Morphine And is ?s iU\ $ a JG STORE. J ? WlMr w v ^ ^ . J 1XJC.WO. Old People \ vi * _..! ... V vJiv?JL\s . o'.reir -'.hcuo and vitalizes \ i:i>>! i? !:t's up the digestive organs, Is assimilation, enriches the blood, kI rejuvenates every ? rtr;i11 in the I.' >>!i 11?i < nut ura\ i!i,inner \'inol I pi.tec.S weakness Willi strength. AVoure positive it will benefit every h Id person \\!?o will ?xive i! n (rial*. Iit duiTt e will rcl iiikI t heir money, /iiliam E. Pelham & Son, ^ Newberry, 3. C. [ EVE SYMPTOMS || l>o not akvavs make llicir |nosi*ticc |! known by failing of sijilil. i 0 Red Lids, Headaches, |i Nervousness, j! Stomach Disorders, I in most eases can In- traced t?> iin- 8' pel leet < ?ns of 111? eves. k| We tl<? e re 11 mil ties ni' the ;tl?ove A kind with glasses. !; [ DR. G. W. CONNOR, Newberry, S. C. Office Over Copelatid Bros. Slore. i MMKMBWBraMWBHaHaMinB I'ATK OK SOl'Tl I CAROLINA, OOl'NTY OK N KWIiKKKY. { IN COl'KT COMMON I Mi HAS. Martha L. Kpfing, Mary M. Leitz- ' y, Amelia L. Wicker and Maggie K. ile. Plaintiffs, Against \ William M. Kidleliuber .1. II. Kidlinber, .1. 1). Widichuher, Wallet Kidleliuber, Christian Suber, Tate * dier and The Setzler Company, 1 )emlnuts. I Partition. By order ol' I lie eoiirl herein, I wilt I II before lite eo:tr| house door at | cwherry, S. (\, on Monday, l lie 71 ii iv of December. 100S, the same heir saleday, within the lepra I hours ' sale, to the highest bidder, the real late in Newberry county of which illiam L. Ridlehuher died seized, mtaining three hundred and t wen(d20) acres, more or less, hound1 by lands of R. I. Slack. \V. T. pting, \\ . 1(. licilzsey, (Jcorne linnrick and others. Said lands will hi. >hl in three separate tracts as fol\vs: Tract No. 1, the home tract, eonlining one hundred and five an<l ie-1 ourth (10.) I-1) acres, more m ss. hounded by Iracls No. 2 and ". .! and land ol \\ . ILeitzsev. Trad N'o. 2. containing one hint red and seven and fonr-l'iflhs (107 5) acres, more or less and bounded ^ lands ol Dave Suber, (feorgc linnrick and Iracls No. 1 and No. 3. I racl No. .5, conlai11in<j one liunrod and nine and fi flv-five-one indrellis (Id.) o.i-IOD) acres, more less, and hounded by tracts No. I id No. 2 and lands of Dave Subei, 'arren Kptinjr. D. A. Dickerl, Ii. I. ? lack and W. L. Leilzsey. I la Is will be exhibited on dav id le. IVrms of' sale: The purchaser to pa\ 10-1 hird cash and give his bond and mortgage ol the premises for the edit port ion of the purchase moue\,| i.vable in two equal annual instalI'tils. with inleresl from I lie day of j le al I lie rale of eiirhl per cent. ( 1 vable annually until I he debt is id, with leave lo anticipate pay'tit of the credit portion in whole in part. Purchaser to pay for pars and recording of same. H. IT. Rikard, Master. Master's Office, Nov. 10, 1008. j D_ nUBfS mmn j IlaliitH enrnri rtt my Sanatorium In n few wpekH. You enn return to your ' . tiomo in 30 <lny? well, frco it ml linppy. I J I hrtvo rnnito tliooo ImliitH n s|vclnliy for I 2.J yfitrn ami cnrdl IbotiN.-wnlK, urtrT' Ilookon Homo Trout moot m-nt |" flLli Address l?R, II. M. WOOl.M'.v, | *Oa N. Pryor Otreot, Atlanta, Om. 11J Ji Ultai1 rt /CTiat ^ ft | jiyfUTW 1 l\I ^ O A Chec I A C 9 S t*ie 'oss A ^ ^ careless | *T^II IS method demands that t< * you ktvj* your nioiuv ? j in lie hank wlu-re wo employ olu Ij every means to make it se- ;uv > I'liiv We ;iu' responsible I***i ^i^ | loss when tunds are in oui by | care. We ?iw you safety. v,a\ \ I hi?* ts :<n absolufolv v 'iii.-,. u;'. I 11 n- n i s} u f h 0> $ * w w m a w ,f i nb jwossBIrI : Ii NEWBERRY J NO. M. KIN A UP, O. \\. MA President. Yiee-l'res TO r> h w Huv Hf rnnfota7 jol A.V We provide easy terms c We enable borrowers to n Monthly Installments, o allowed to meet obligation It is cheaper than paying to save money to buy a hoi Contract. If you want to save mom take a Security Contract. Call on A. J. Gibson, Ass Treasurer, at office* corne Btrt?ets, next door to Copel SECURITY LOAN AND I yf*/! Wf I If yon are fooling ont'of-r.ortr, ~ let, and you will fool lienor 1 % W i T) oy will make you foe 1 JiiLt j M REMEDY" fctmiicthniis tin; Stonwi and pnrlOos tint I. doe* Its \v Vf pleasantly, yet It nover ciiprs, * fgy invariably making the user (? ol -ti U Better Than Pilis Fc B Take NH Ynlilcls for ImtlgOAtion, K 0 Appotltc. Sallow Complexion, Llvcl C<>i a Plrnplos and Eruptions, OliillK, Malar! B tlsin, Torpid l,ivor or Inactive Klducyn m from the digestive organs,. N i f*co u .1 /Mr c\rm ^ Box. William E. Pelham & Sor ?M?i?ngMa*uaa?^???i'jag?c.?iMer?BAKxnBei?ntMBanB?i YOUR BA THE NEWBERRY SI Capital $50,000 No Matter How Small, N The Newberry Se vill give it careful attonti i.pp'ies to the man and the IAS. MciNTOSH. P resident. SEVEN :k Account prevents i of money by theft, ness or accident. I/ ' I H your money in the * l);mk, \nii may issue a ok against it. Your cheeks >;ood only wlit 11 properly M iutl, and (,' vn In.- cached only I he party to whom you e it. who mv.M endorse it. I sate ?.*onv.Miionce 1 ... N \V 5 \ \'. > ! c (t U r :inl Honk, I / o p ;1 , O. V-S, ? Money >rn lis Jd\. i& VJ >f payment, accumulate a fund n which interest is s at maturity. rent. If you want me take a Security 3y for any purpose It pays. tant Secretary and r Boyce and Adams land Brothers. NVESTMENT CO. BBKEOfiX,, A O, taVi-> an Nil T.ib- /|J\ Vr n t ).< intrnihit. %IJJ/ irht. "MATuncs yjj f ?r Lavcv Ills. 91 tek Ilriwlftrhf!, Irfiss of vyi a, }'i!;<?tiF!irt.K. Khcunia* i*n*l all troubles arising M vtff w:q rr. i.ruvni*i rr*mmmmiamaaummm GIVES RELIEf. i, Newberry, S. C. NKING! IVINGS BANK. Surplus $80,000 'o Matter How Large, ivings Bank on. This meGsajyfj women alike. ?L NORWOOD, Ca.; /sr.